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In addition, enzymes, such as xanthine oxidase, NADPH oxidase (NOX), and myeloperoxidase (MPO), become overtly hyperactive during reperfusion and significantly contribute to the production of ROS (Sasaki and Joh, 2007

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This group of antioxidants is often referred to as radical scavenger as they dispose of FR by inhibiting the start of the oxidation chain and break chain propagation reactions, either by reducing or eliminating FR by donating one electron to them, without becoming free radicals or poorly reactive free radicals, with less damaging effects [16,17]